In groups, as a conclusion to the seed germination experiments, they will investigate the effect of a chemical (they choose) on the germination of seeds and will create a dose-response curve to interpret their observations and evaluate their hypothesis.
Students will be able to:
- Define a “toxic substance.”
- Define the “science of toxicology.”
- Explain the dose-response principle.
- Explain toxicological principles that govern the safety of a substance.
- Analyze toxicological risks versus benefits of a substance based on their understanding of toxicological principles.
- Draw conclusions and evaluate hypotheses
National Science Education Standard
Content Standard A – Science as Inquiry
- Identify questions and concepts that guide scientific investigations
- Formulate and revise scientific explanations and models using logic and evidence
- Communicate and defend a scientific argument
Content Standard F- Science in Personal and Social Perspectives
Personal and community health
Arizona Science Education Standards:
Concept 1: Observations, Questions, and Hypotheses
- PO 2. Develop questions from observations that transition into testable hypotheses.
- PO 3. Formulate a testable hypothesis.
Concept 2: Scientific Testing (Investigating and Modeling)
- PO 1. Demonstrate safe and ethical procedures (e.g., use and care of technology, materials, organisms) and behavior in all science inquiry.
- PO 5. Record observations, notes, sketches, questions, and ideas using tools such as journals, charts, graphs, and computers.
Concept 3: Analysis, Conclusions, and Refinements
- PO 2. Evaluate whether investigational data support or do not support the proposed hypothesis.
Concept 4: Communication
- PO 2. Produce graphs that communicate data. (See MHS-S2C1-02)
- PO 3. Communicate results clearly and logically.
- PO 4. Support conclusions with logical scientific arguments.
See Basic Toxicology under the Environmental Health Resources section of PULSE.
See also the background section for the ‘The Science Behind Our Food” unit http://apps.caes.uga.edu/sbof/main/lessonPlan/IntroToToxicology.pdf
Dose Response Relationships http://science.education.nih.gov/supplements/nih2/chemicals/guide/lesson3-1.htm
Related and Resource Websites
Dose-Response Relationships In Toxicology http://pmep.cce.cornell.edu/profiles/extoxnet/TIB/dose-response.html, an in-depth overview of dose-response
Green Facts Glossary http://www.greenfacts.org/glossary/def/dose-response-relationship-dose-response.htm, an overview of dose-response for certain chemicals and links to other toxicology terms
Health and the Environment: Food, Farming, & Pesticides http://www.nrdc.org/health/pesticides/default.asp
Develop a hypothesis http://www.k12science.org/curriculum/dipproj2/en/lesson1.shtml
Writing a hypothesis: a student lesson http://www.accessexcellence.org/LC/TL/filson/writhypo.html
Case Study: Polio http://www.the-aps.org/pa/animals/polio.html
Questions People Ask About Animals in Research http://www.the-aps.org/pa/animals/index.htm